Catalytic Cleavage of C(sp2)-C(sp2) Bonds with Rh-Carbynoids

J Am Chem Soc. 2019 Oct 2;141(39):15509-15514. doi: 10.1021/jacs.9b08632. Epub 2019 Sep 19.

Abstract

We report a catalytic strategy that generates rhodium-carbynoids by selective diazo activation of designed carbyne sources. We found that rhodium-carbynoid species provoke C(sp2)-C(sp2) bond scission in alkenes by inserting a monovalent carbon unit between both sp2-hybridized carbons. This skeletal remodeling process accesses synthetically useful allyl cation intermediates that conduct to valuable allylic building blocks upon nucleophile attack. Our results rely on the formation of cyclopropyl-I(III) intermediates able to undergo electrocyclic ring-opening, following the Woodward-Hoffmann-DePuy rules.

Publication types

  • Research Support, Non-U.S. Gov't