Investigation of the relationship between IL-6 and type 2 biomarkers in patients with severe asthma

Xingnan Li; Annette T Hastie; Michael C Peters; Gregory A Hawkins; Wanda Phipatanakul; Huashi Li; Wendy C Moore; William W Busse; Mario Castro; Serpil C Erzurum; Benjamin Gaston; Elliot Israel; Nizar N Jarjour; Bruce D Levy; Sally E Wenzel; Deborah A Meyers; John V Fahy; Eugene R Bleecker; National Heart, Lung, and Blood Institute's Severe Asthma Research Program (SARP) Networks

doi:10.1016/j.jaci.2019.08.031

Investigation of the relationship between IL-6 and type 2 biomarkers in patients with severe asthma

J Allergy Clin Immunol. 2020 Jan;145(1):430-433. doi: 10.1016/j.jaci.2019.08.031. Epub 2019 Sep 9.

Authors

Xingnan Li¹, Annette T Hastie², Michael C Peters³, Gregory A Hawkins⁴, Wanda Phipatanakul⁵, Huashi Li⁶, Wendy C Moore², William W Busse⁷, Mario Castro⁸, Serpil C Erzurum⁹, Benjamin Gaston¹⁰, Elliot Israel¹¹, Nizar N Jarjour⁷, Bruce D Levy¹¹, Sally E Wenzel¹², Deborah A Meyers⁶, John V Fahy³, Eugene R Bleecker⁶; National Heart, Lung, and Blood Institute's Severe Asthma Research Program (SARP) Networks

Affiliations

¹ Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, Ariz. Electronic address: lixingnan1@deptofmed.arizona.edu.
² Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
³ Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California at San Francisco, San Francisco, Calif.
⁴ Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC.
⁵ Boston Children's Hospital, Boston, Mass; Division of Allergy and Immunology, Harvard Medical School, Boston, Mass.
⁶ Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, Ariz.
⁷ Department of Medicine, University of Wisconsin School of Medicine, Madison, Wis.
⁸ Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, Mo.
⁹ Lerner Research Institute, Cleveland, Ohio.
¹⁰ Division of Pediatric Pulmonology, Rainbow Babies and Children's Hospital and Cleveland Medical Center, Cleveland, Ohio.
¹¹ Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
¹² Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pa.

Abstract

Combination of IL-6 (non-Type 2 asthma) and FeNO or blood eosinophil count (Type 2 asthma) identified asthma endotypes related to asthma severity, exacerbations, and responsiveness to corticosteroids and potential for response to anti-Type 2 and anti-IL-6 treatment.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adolescent
Adult
Asthma / blood*
Asthma / immunology
Biomarkers / blood
Child
Female
Humans
Interleukin-6 / blood*
Interleukin-6 / immunology
Male
Severity of Illness Index

Substances

Biomarkers
IL6 protein, human
Interleukin-6

Abstract

Publication types

MeSH terms

Substances

Grants and funding