Pathogen Reduction: The State of the Science in 2019

Eric A Gehrie; Sara J Rutter; Edward L Snyder

doi:10.1016/j.hoc.2019.05.001

Pathogen Reduction: The State of the Science in 2019

Hematol Oncol Clin North Am. 2019 Oct;33(5):749-766. doi: 10.1016/j.hoc.2019.05.001. Epub 2019 Jul 9.

Authors

Eric A Gehrie¹, Sara J Rutter², Edward L Snyder³

Affiliations

¹ Department of Pathology, Division of Transfusion Medicine, The Johns Hopkins University School of Medicine, 1800 Orleans Street, Zayed Tower Suite 3081A, Baltimore, MD 21287, USA.
² Department of Laboratory Medicine, Yale University School of Medicine, 20 York Street, New Haven, CT 06510, USA.
³ Department of Laboratory Medicine, Yale University School of Medicine, 20 York Street, New Haven, CT 06510, USA. Electronic address: Edward.Snyder@yale.edu.

PMID: 31466602
DOI: 10.1016/j.hoc.2019.05.001

Abstract

In the past 30 years, transfusion safety has increased substantially and blood transfusion is now a safer procedure than at any time in the past. Herein, we provide a comprehensive review of pathogen reduction, which is the new paradigm in transfusion safety. Specifically, we describe the various processes and technologies that are capable of diminishing or neutralizing infectious threats, including those that are not addressed or may not be detected by standard screening techniques. A special emphasis is placed on recent developments that are likely to impact patient care in 2019 and beyond.

Keywords: Blood transfusion; Pathogen reduction; Plasma transfusion; Platelet transfusion; Red blood cell transfusion; Transfusion-transmitted infection.

Publication types

Review

MeSH terms

Biotechnology / methods
Biotechnology / standards
Blood Component Transfusion / methods
Blood Component Transfusion / standards
Blood Safety* / economics
Blood Safety* / methods
Blood Transfusion / methods
Blood Transfusion / standards*
Blood-Borne Pathogens*
Humans