The Molecular Diversity of Vagal Afferents Revealed

Kristoffer L Egerod; Thue W Schwartz; Laurent Gautron

doi:10.1016/j.tins.2019.08.002

The Molecular Diversity of Vagal Afferents Revealed

Trends Neurosci. 2019 Oct;42(10):663-666. doi: 10.1016/j.tins.2019.08.002. Epub 2019 Aug 14.

Authors

Kristoffer L Egerod¹, Thue W Schwartz¹, Laurent Gautron²

Affiliations

¹ Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
² Division of Hypothalamic Research and Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA. Electronic address: Laurent.gautron@UTSouthwestern.edu.

PMID: 31421944
DOI: 10.1016/j.tins.2019.08.002

Abstract

Using single-cell RNA sequencing (RNA-seq), Kupari and coworkers (Cell Rep., 2019) have generated a long sought-after molecular atlas of vagal afferents in the mouse. Vagal afferents were found to be organized into 24 subtypes, revealing a level of diversity that was not previously recognized.

Keywords: autonomic nervous system; single cell; transcriptomics; vagus nerve.

Publication types

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MeSH terms

Animals
Mice
Sensory Receptor Cells*
Vagus Nerve*