Birth and coming of age of islet autoantibodies

E Bonifacio; P Achenbach

doi:10.1111/cei.13360

Birth and coming of age of islet autoantibodies

Clin Exp Immunol. 2019 Dec;198(3):294-305. doi: 10.1111/cei.13360. Epub 2019 Sep 12.

Authors

E Bonifacio^{1

2}, P Achenbach^{3

4}

Affiliations

¹ Technische Universität Dresden, DFG Center for Regenerative Therapies Dresden, Dresden, Germany.
² Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital Carl Gustav Carus and Faculty of Medicine, TU Dresden, Dresden, Germany.
³ Institute of Diabetes Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany.
⁴ Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Forschergruppe Diabetes, Munich, Germany.

Abstract

This review takes the reader through 45 years of islet autoantibody research, from the discovery of islet-cell antibodies in 1974 to today's population-based screening for presymptomatic early-stage type 1 diabetes. The review emphasizes the current practical value of, and factors to be considered in, the measurement of islet autoantibodies.

Keywords: Autoantibodies; ICA; Islet-cell antibodies; Type 1 diabetes.

Publication types

Review

MeSH terms

Antibody Specificity / immunology
Autoantibodies / immunology*
Autoimmunity / immunology
Diabetes Mellitus, Type 1 / diagnosis
Diabetes Mellitus, Type 1 / immunology*
Glutamate Decarboxylase / immunology
Humans
Islets of Langerhans / immunology*
Mass Screening / methods
Population Surveillance / methods

Substances

Autoantibodies
islet cell antibody
Glutamate Decarboxylase