UBE2S Learns Self-Control

Tatyana Bodrug; Nicholas G Brown

doi:10.1016/j.str.2019.07.009

UBE2S Learns Self-Control

Structure. 2019 Aug 6;27(8):1185-1187. doi: 10.1016/j.str.2019.07.009.

Authors

Tatyana Bodrug¹, Nicholas G Brown²

Affiliations

¹ Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
² Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: nbrown1@med.unc.edu.

Abstract

In this issue of Structure, Liess et al. (2019) demonstrate that the cell cycle regulator UBE2S shuts itself off through autoubiquitination at a conserved lysine residue. Since E2s are at the center of the ubiquitination cascade, this presents a possible regulatory mechanism in a multitude of cellular processes.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Lysine
Self-Control*
Ubiquitin-Conjugating Enzymes*
Ubiquitination

Substances

Ubiquitin-Conjugating Enzymes
Lysine

Abstract

Publication types

MeSH terms

Substances

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