Gut-Brain Interactions: Implications for a Role of the Gut Microbiota in the Treatment and Prognosis of Anorexia Nervosa and Comparison to Type I Diabetes

Gastroenterol Clin North Am. 2019 Sep;48(3):343-356. doi: 10.1016/j.gtc.2019.04.003. Epub 2019 Jun 25.

Abstract

Anorexia nervosa has poor prognosis and treatment outcomes and is influenced by genetic, metabolic, and psychological factors. Gut microbes interact with gut physiology to influence metabolism and neurobiology, although potential therapeutic benefits remain unknown. Type 1 diabetes is linked to anorexia nervosa through energy dysregulation, which in both disease states is related to the gut microbiota, disordered eating, and genetics.

Keywords: Anorexia nervosa; Diabetes; Metabolism; Microbiome; Microbiota.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Anorexia Nervosa / etiology*
  • Anorexia Nervosa / therapy*
  • Brain / physiology*
  • Diabetes Mellitus, Type 1 / etiology*
  • Diabetes Mellitus, Type 1 / therapy*
  • Gastrointestinal Microbiome / physiology*
  • Humans
  • Prognosis