Cutting Off Leukemogenesis: Hydra-like Plasticity of Mature Leukemic Cells

Shiva Bamezai; Christian Buske

doi:10.1016/j.stem.2019.07.005

Cutting Off Leukemogenesis: Hydra-like Plasticity of Mature Leukemic Cells

Cell Stem Cell. 2019 Aug 1;25(2):167-168. doi: 10.1016/j.stem.2019.07.005.

Authors

Shiva Bamezai¹, Christian Buske²

Affiliations

¹ Institute of Experimental Cancer Research, CCC Ulm, University Hospital Ulm, Ulm, Germany.
² Institute of Experimental Cancer Research, CCC Ulm, University Hospital Ulm, Ulm, Germany. Electronic address: christian.buske@uni-ulm.de.

PMID: 31374194
DOI: 10.1016/j.stem.2019.07.005

Abstract

Leukemic stem cells (LSCs) in acute myeloid leukemia (AML) can drive tumor growth and relapse. In this issue of Cell Stem Cell, McKenzie et al. (2019) report that some mature leukemic cells can de-differentiate and contribute to AML tumorigenesis, a finding with important implications for therapies focused on eradicating LSCs.

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MeSH terms

Animals
Carcinogenesis
Cell Differentiation
Hydra*
Leukemia, Myeloid, Acute*