Hallmarks of cancer: Tumor budding as a sign of invasion and metastasis in head and neck cancer

Antti A Mäkitie; Alhadi Almangush; Juan P Rodrigo; Alfio Ferlito; Ilmo Leivo

doi:10.1002/hed.25872

Hallmarks of cancer: Tumor budding as a sign of invasion and metastasis in head and neck cancer

Head Neck. 2019 Oct;41(10):3712-3718. doi: 10.1002/hed.25872. Epub 2019 Jul 22.

Authors

Antti A Mäkitie^{1

2

3}, Alhadi Almangush^{2

4

5

6}, Juan P Rodrigo⁷, Alfio Ferlito⁸, Ilmo Leivo⁵

Affiliations

¹ Department of Otorhinolaryngology, Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Finland.
² Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
³ Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institute and Karolinska Hospital, Stockholm, Sweden.
⁴ Department of Pathology, University of Helsinki, Helsinki, Finland.
⁵ Institute of Biomedicine, Pathology, University of Turku, Turku, Finland.
⁶ Institute of Dentistry, University of Misurata, Misurata, Libya.
⁷ Department of Otolaryngology, Hospital Universitario Central de Asturias, University of Oviedo, ISPA, IUOPA, CIBERONC, Oviedo, Spain.
⁸ Coordinator of the International Head and Neck Scientific Group, Padua, Italy.

PMID: 31328847
DOI: 10.1002/hed.25872

Abstract

Invasion and metastasis are hallmarks of cancer. The concept of tumor budding at tumor-host interface has been documented in many carcinomas. A growing body of evidence indicates that tumor budding is a sign of invasion and early step for metastasis of many epithelial cancers including head and neck squamous cell carcinoma (HNSCC). In addition, recent research has underlined the importance of tumor budding as a promising prognosticator in HNSCC. This review summarizes the findings regarding tumor budding in HNSCC and focuses on the role of tumor budding in invasion and metastasis. Also, we highlight the prognostic significance of tumor budding in HNSCC and its potential for improving clinical decision making in terms of recommending optimal individualized treatment for this patient population.

Keywords: head and neck squamous cell carcinoma (HNSCC); invasion; metastasis; tumor budding.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Disease Progression
Disease-Free Survival
Female
Head and Neck Neoplasms / mortality
Head and Neck Neoplasms / pathology*
Head and Neck Neoplasms / therapy*
Humans
Male
Neoplasm Invasiveness / pathology
Neoplasm Metastasis / pathology
Neoplasm Staging
Prognosis
Risk Assessment
Squamous Cell Carcinoma of Head and Neck / mortality
Squamous Cell Carcinoma of Head and Neck / pathology*
Squamous Cell Carcinoma of Head and Neck / therapy*
Survival Analysis
Tumor Burden

Abstract

Publication types

MeSH terms

Grants and funding