Reduced virulence in ciprofloxacin-resistant variants of Pseudomonas aeruginosa strains

G Ravizzola; F Pirali; A Paolucci; L Terlenghi; L Peroni; A Colombi; A Turano

doi:10.1093/jac/20.6.825

Reduced virulence in ciprofloxacin-resistant variants of Pseudomonas aeruginosa strains

J Antimicrob Chemother. 1987 Dec;20(6):825-9. doi: 10.1093/jac/20.6.825.

Authors

G Ravizzola¹, F Pirali, A Paolucci, L Terlenghi, L Peroni, A Colombi, A Turano

Affiliation

¹ Institute of Microbiology, University of Brescia, Italy.

PMID: 3126177
DOI: 10.1093/jac/20.6.825

Abstract

Pseudomonas aeruginosa strains resistant to ciprofloxacin were obtained from parental strains by serial transfer through subinhibitory concentrations of the drug. They showed reduced virulence for mice, and also increased sensitivity to aminoglycosides.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aminoglycosides
Animals
Anti-Bacterial Agents / pharmacology
Ciprofloxacin / pharmacology*
Drug Resistance, Microbial
Female
Lethal Dose 50
Male
Mice
Pseudomonas aeruginosa / drug effects
Pseudomonas aeruginosa / genetics
Pseudomonas aeruginosa / pathogenicity*
Species Specificity
Virulence

Substances

Aminoglycosides
Anti-Bacterial Agents
Ciprofloxacin