Airway Histopathology of Adolescent Survivors of Bronchopulmonary Dysplasia

Alfonso Galderisi; Fiorella Calabrese; Francesco Fortarezza; Steve Abman; Eugenio Baraldi

doi:10.1016/j.jpeds.2019.04.006

Airway Histopathology of Adolescent Survivors of Bronchopulmonary Dysplasia

J Pediatr. 2019 Aug:211:215-218. doi: 10.1016/j.jpeds.2019.04.006. Epub 2019 May 7.

Authors

Alfonso Galderisi¹, Fiorella Calabrese², Francesco Fortarezza², Steve Abman³, Eugenio Baraldi⁴

Affiliations

¹ Department of Woman's and Child's Health - University Hospital of Padova, Padova, Italy.
² Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
³ Pediatric Heart and Lung Center - University of Colorado, Aurora, CO.
⁴ Department of Woman's and Child's Health - University Hospital of Padova, Padova, Italy. Electronic address: eugenio.baraldi@unipd.it.

PMID: 31076230
DOI: 10.1016/j.jpeds.2019.04.006

Abstract

Long-term survivors of bronchopulmonary dysplasia develop chronic obstructive lung disease. Herein we report in vivo histopathology from bronchial biopsies of 3 adolescent survivors of severe bronchopulmonary dysplasia. Thickened basement membranes with lymphocytic infiltrates and signs of immature neoangiogenesis in the absence of T-helper lymphocytes or eosinophils suggest the presence of an ongoing active airway process.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Biopsy
Bronchi / metabolism
Bronchi / pathology*
Bronchopulmonary Dysplasia / pathology*
Bronchoscopy
CD8-Positive T-Lymphocytes / metabolism
Child
Female
Fibrosis
Humans
Infant, Newborn
Infant, Premature
Male
Respiratory Function Tests
Respiratory Mucosa / pathology
Respiratory Sounds
Survivors*