Gastric cancer in Lynch syndrome is associated with underlying immune gastritis

J Med Genet. 2019 Dec;56(12):844-845. doi: 10.1136/jmedgenet-2018-105757. Epub 2019 May 4.
No abstract available

Keywords: cancer: gastric; clinical genetics; genetic screening/counselling; screening.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Colorectal Neoplasms, Hereditary Nonpolyposis / diagnosis
  • Colorectal Neoplasms, Hereditary Nonpolyposis / genetics*
  • Colorectal Neoplasms, Hereditary Nonpolyposis / immunology
  • Colorectal Neoplasms, Hereditary Nonpolyposis / microbiology
  • DNA-Binding Proteins / genetics
  • Epithelial Cell Adhesion Molecule / genetics
  • Female
  • Gastritis / diagnosis
  • Gastritis / genetics*
  • Gastritis / immunology
  • Gastritis / microbiology
  • Genetic Testing / methods
  • Germ-Line Mutation / genetics
  • Helicobacter Infections / diagnosis
  • Helicobacter Infections / genetics*
  • Helicobacter Infections / immunology
  • Helicobacter Infections / microbiology
  • Humans
  • Male
  • Middle Aged
  • Mismatch Repair Endonuclease PMS2 / genetics
  • MutL Protein Homolog 1 / genetics
  • MutS Homolog 2 Protein / genetics
  • Stomach Neoplasms / diagnosis
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / immunology
  • Stomach Neoplasms / microbiology

Substances

  • DNA-Binding Proteins
  • EPCAM protein, human
  • Epithelial Cell Adhesion Molecule
  • G-T mismatch-binding protein
  • MLH1 protein, human
  • PMS2 protein, human
  • MSH2 protein, human
  • Mismatch Repair Endonuclease PMS2
  • MutL Protein Homolog 1
  • MutS Homolog 2 Protein