Histone Serotonylation: Can the Brain Have "Happy" Chromatin?

Jamie N Anastas; Yang Shi

doi:10.1016/j.molcel.2019.04.017

Histone Serotonylation: Can the Brain Have "Happy" Chromatin?

Mol Cell. 2019 May 2;74(3):418-420. doi: 10.1016/j.molcel.2019.04.017.

Authors

Jamie N Anastas¹, Yang Shi²

Affiliations

¹ Division of Newborn Medicine and Epigenetics Program, Department of Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
² Division of Newborn Medicine and Epigenetics Program, Department of Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: yang_shi@hms.harvard.edu.

Abstract

Recent work from Farrelly et al. (2019) indicates that histone tails can be serotonylated, suggesting a previously unappreciated direct mechanism of potential crosstalk between bioactive amines and the epigenome.

Publication types

Comment

MeSH terms

Brain
Chromatin*
Histones*
Transcription Factor TFIID

Substances

Chromatin
Histones
Transcription Factor TFIID

Grants and funding

R35 CA210104/CA/NCI NIH HHS/United States