Mesenchymal stem cell therapy targeting mitochondrial dysfunction in acute kidney injury

Lingfei Zhao; Chenxia Hu; Ping Zhang; Hua Jiang; Jianghua Chen

doi:10.1186/s12967-019-1893-4

Mesenchymal stem cell therapy targeting mitochondrial dysfunction in acute kidney injury

J Transl Med. 2019 May 2;17(1):142. doi: 10.1186/s12967-019-1893-4.

Authors

Lingfei Zhao^{1

2

3}, Chenxia Hu⁴, Ping Zhang^{1

2

3}, Hua Jiang^{1

2

3}, Jianghua Chen^{5

6

7}

Affiliations

¹ Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
² Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, Zhejiang, People's Republic of China.
³ Institute of Nephrology, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
⁴ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
⁵ Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China. zjukidney@zju.edu.cn.
⁶ Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, Zhejiang, People's Republic of China. zjukidney@zju.edu.cn.
⁷ Institute of Nephrology, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China. zjukidney@zju.edu.cn.

Abstract

Mitochondria take part in a network of cellular processes that regulate cell homeostasis. Defects in mitochondrial function are key pathophysiological changes during acute kidney injury (AKI). Mesenchymal stem cells (MSCs) have shown promising regenerative effects in experimental AKI models, but the specific mechanism is still unclear. Some studies have demonstrated that MSCs are able to target mitochondrial dysfunction during AKI. In this review, we summarize these articles, providing an integral and updated view of MSC therapy targeting mitochondrial dysfunction during AKI, which is aimed at promoting the therapeutic effect of MSCs in AKI patients.

Keywords: Acute kidney injury; Mesenchymal stem cells; Mitochondrial dysfunction.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Acute Kidney Injury / pathology
Acute Kidney Injury / physiopathology*
Acute Kidney Injury / therapy*
Animals
Humans
Mesenchymal Stem Cell Transplantation*
Mesenchymal Stem Cells / cytology*
Mitochondria / pathology*
Mitochondria / ultrastructure
Mitophagy
Models, Biological