Body Surface Area-Based Dosing Regimen of Caspofungin in Children: a Population Pharmacokinetics Confirmatory Study

Antimicrob Agents Chemother. 2019 Jun 24;63(7):e00248-19. doi: 10.1128/AAC.00248-19. Print 2019 Jul.

Abstract

We evaluated the population pharmacokinetics of caspofungin in children (2 to 12 years of age). The real-world data from 48 children were best fit by a two-compartment model with first-order elimination. Subsequent covariate analysis demonstrated that body surface area had a significant correlation with caspofungin pharmacokinetics, compared to body weight. The population pharmacokinetics of caspofungin confirmed that adjustment of caspofungin dosage based on body surface area is most appropriate for pediatric use.

Keywords: caspofungin; children; developmental pharmacokinetics; dose.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Body Surface Area
  • Caspofungin / administration & dosage*
  • Caspofungin / pharmacokinetics*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Microbial Sensitivity Tests

Substances

  • Caspofungin