[The schizophrenic's chilhood]

Encephale. 2018 Dec;44(6S):S12-S16. doi: 10.1016/S0013-7006(19)30072-7.
[Article in French]

Abstract

Pathology of adolescence and young adult, schizophrenia can begin in very rare cases during childhood. Two early clinical forms of the disorder have been identified by epidemiological studies: one beginning at the age of 15; the other around 9 years old; While many questions remain unsanswered about the neurobiological and environmental factors - common or distinct - of these two clinical phenotype, both are related to a profoun and lasting alteration of the neurocognitive development whose origin would clearly go back to infancy or to the antenal period. Here we will present a possible story back of schizophrenia in the light of the latest neuroscientific studies in imagery and genetics from adolescence to antenal period.

Keywords: Development; Développement; Infant schizophrenia; Schizophrénie infantile; Trajectoire; Trajectory.

MeSH terms

  • Adolescent
  • Age of Onset
  • Brain / pathology
  • Brain / physiopathology
  • Child
  • Disease Susceptibility
  • Female
  • Humans
  • Pregnancy
  • Prenatal Exposure Delayed Effects / physiopathology
  • Prenatal Exposure Delayed Effects / psychology
  • Risk Factors
  • Schizophrenia / diagnosis
  • Schizophrenia / epidemiology*
  • Schizophrenia / etiology
  • Schizophrenia / pathology