Nonalcoholic steatohepatitis (NASH) may progress to end-stage liver disease, and needs medical intervention. Hepatocellular carcinoma (HCC) may occur in patients with NASH prior to occurrence of cirrhosis. There is paucity of knowledge in understanding how NASH progresses to HCC. The present overview intends to provide updates in clinical and basic research of NASH-HCC, challenges and strategies in understanding its pathogenesis and solutions to increased incidence.
非酒精性脂肪性肝炎可进展为终末期肝病。部分非酒精性脂肪性肝炎在进展至肝硬化前即可发生肝细胞癌。非酒精性脂肪性肝炎如何发生肝癌的分子基础目前知之甚少，逐渐得到肝病领域的重视。现概述非酒精性脂肪性肝炎相关肝细胞癌临床及基础研究，介绍对非酒精性脂肪性肝炎相关肝细胞癌现有的认识、遇到的困境、常用的方法及急需的对策。.
Keywords: Carcinoma, hepatocellular; Fatty liver, non-alcoholic; Non-alcoholic steatohepatitis.