Myelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signaling

Haematologica. 2019 Sep;104(9):e388-e392. doi: 10.3324/haematol.2018.214155. Epub 2019 Mar 7.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cytokines / metabolism
  • Humans
  • Immunity, Innate*
  • Inflammation
  • K562 Cells
  • Lipopolysaccharides
  • Mice
  • Mutation
  • Myelodysplastic Syndromes / genetics*
  • NF-kappa B p50 Subunit / metabolism
  • Phenotype
  • Phosphoproteins / genetics*
  • RAW 264.7 Cells
  • RNA Splicing
  • RNA Splicing Factors / genetics*
  • Serine-Arginine Splicing Factors / genetics*
  • Spliceosomes / genetics*
  • Splicing Factor U2AF / genetics*

Substances

  • Cytokines
  • Lipopolysaccharides
  • NF-kappa B p50 Subunit
  • NFKB1 protein, human
  • Phosphoproteins
  • RNA Splicing Factors
  • SF3B1 protein, human
  • SRSF2 protein, mouse
  • Sf3b1 protein, mouse
  • Splicing Factor U2AF
  • U2AF1 protein, human
  • Zrsr1 protein, mouse
  • SRSF2 protein, human
  • Nfkb1 protein, mouse
  • Serine-Arginine Splicing Factors