A role for FNDC5/Irisin in the beneficial effects of exercise on the brain and in neurodegenerative diseases

Prog Cardiovasc Dis. 2019 Mar-Apr;62(2):172-178. doi: 10.1016/j.pcad.2019.02.007. Epub 2019 Mar 4.

Abstract

The beneficial effects of exercise on the brain are well known. However, the underlying molecular mechanisms are much less well understood. Interestingly, myokines, hormones secreted by muscle in response to exercise, gained attention as such beneficial mediators. In this review, we will focus on FNDC5 and its secreted form, the newly discovered myokine "irisin". We will discuss their role in the beneficial effects of exercise and its potential application in neurodegenerative disorders.

Keywords: Cognition; Exercise; FNDC5; Hippocampus; Irisin; Neurodegeneration; Physical activity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Brain / metabolism*
  • Cognition / physiology
  • Exercise / physiology*
  • Fibronectins* / blood
  • Fibronectins* / metabolism
  • Humans
  • Muscle, Skeletal / metabolism
  • Neurodegenerative Diseases* / metabolism
  • Neurodegenerative Diseases* / prevention & control
  • Neuroprotection / physiology

Substances

  • FNDC5 protein, human
  • Fibronectins