The role of the erythrocyte in the outcome of pregnancy with preeclampsia

PLoS One. 2019 Mar 6;14(3):e0212763. doi: 10.1371/journal.pone.0212763. eCollection 2019.

Abstract

The objective of this study was to analyze the relationships of osmotic and mechanical stability of erythrocytes with anthropometric, biochemical, hematologic and hemodynamic variables in pregnant women with preeclampsia (PE). The studied population consisted of 20 normotensive patients and 16 patients with PE. Patients with PE presented worse gestational outcome, greater hematologic impairment, erythrocytes osmotically more stable in vitro, but in conditions of isotonicity with the in vivo medium, in addition to hyperflow in orbital territory, when compared to normotensive patients. The correlation analysis between anthropometric, hematologic and hemodynamic variables in patients with PE indicated that erythrocytes with lower volumes and lower levels of hemoglobin favor the occurrence of a better gestational outcome, because they are more stable and because they are associated with a decrease in the hemodynamic changes present in the disease. This should mean that the tendency to microcytosis, probably due to a mechanism of compensatory mechanical selection, is a desirable characteristic in the disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Pressure
  • Cross-Sectional Studies
  • Erythrocyte Volume*
  • Erythrocytes / metabolism*
  • Female
  • Hemodynamics*
  • Humans
  • Pre-Eclampsia* / blood
  • Pre-Eclampsia* / physiopathology
  • Pregnancy
  • Pregnancy Outcome*

Grants and funding

Productivity Research Grant # 306608/2015-4, in name of Nilson Penha-Silva, from "Conselho Nacional de Desenvolvimento Científico e Tecnológico" (CNPq). The research productivity grant awarded to the corresponding author of this manuscript does not imply any interference by CNPq in the research projects developed by the professor. Post-Doctoral Fellowship # 001, in name of Mario da Silva Garrote Filho, from “Coordenação de Aperfeiçoamento de Pessoal de Nível Superior” (CAPES). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.