Phenotype switch in acute lymphoblastic leukaemia associated with 3 years of persistent CAR T cell directed-CD19 selective pressure

Br J Haematol. 2019 Jul;186(2):333-336. doi: 10.1111/bjh.15812. Epub 2019 Feb 27.
No abstract available

Keywords: KMT2A; PHF6; PTPN11; CAR T cells; lineage switch.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Antigens, CD19 / metabolism*
  • Child, Preschool
  • Humans
  • Immunotherapy, Adoptive*
  • Male
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / metabolism
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / pathology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / therapy

Substances

  • Antigens, CD19
  • CD19 molecule, human