Two-Pronged Control of the Dorsal Raphe by the VTA

Julie A Kauer; Abigail M Polter

doi:10.1016/j.neuron.2019.01.059

Two-Pronged Control of the Dorsal Raphe by the VTA

Neuron. 2019 Feb 20;101(4):553-555. doi: 10.1016/j.neuron.2019.01.059.

Authors

Julie A Kauer¹, Abigail M Polter²

Affiliations

¹ Department of Psychiatry, Stanford University, Palo Alto, CA 94305, USA. Electronic address: jkauer@stanford.edu.
² Department of Pharmacology and Physiology, George Washington University, Washington, DC, 20037, USA.

PMID: 30790535
DOI: 10.1016/j.neuron.2019.01.059

Abstract

In this issue of Neuron, Li et al. (2019) distinguish two separable GABAergic projections from the ventral tegmental area (VTA) to the dorsal raphe nucleus (DRN), with differential μ-opioid receptor regulation, each targeting different postsynaptic neurons and promoting opposing behavioral states.

Publication types

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MeSH terms

Dorsal Raphe Nucleus*
Humans
Neurons
Opioid-Related Disorders*
Ventral Tegmental Area