BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression

Yilei Zhang; Li Zhuang; Boyi Gan

doi:10.1080/23723556.2018.1536845

BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression

Mol Cell Oncol. 2018 Nov 13;6(1):1536845. doi: 10.1080/23723556.2018.1536845. eCollection 2019.

Authors

Yilei Zhang¹, Li Zhuang¹, Boyi Gan¹

Affiliation

¹ Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Abstract

The tumor suppressor BRCA1-associated protein 1 (BAP1) is a deubiquitinase that removes histone 2A ubiquitination. How BAP1 suppresses tumor development remains elusive. Our recent study identified the cystine transporter solute carrier family 7 member 11 (SLC7A11) as a critical BAP1 target, and showed that BAP1 promotes ferroptosis (a non-apoptotic cell death) through repressing SLC7A11 expression, resulting in tumor suppression.

Keywords: BAP1; H2A ubiquitination; SLC7A11; ferroptosis; metabolism; tumor suppression.

Grants and funding

This work was supported by the National Institutes of Health [CA181196];