Hybridization chain reaction-based nanoprobe for cancer cell recognition and amplified photodynamic therapy

Mengyi Xiong; Qiming Rong; Gezhi Kong; Chan Yang; Yan Zhao; Feng-Li Qu; Xiao-Bing Zhang; Weihong Tan

doi:10.1039/c8cc10074h

Hybridization chain reaction-based nanoprobe for cancer cell recognition and amplified photodynamic therapy

Chem Commun (Camb). 2019 Mar 7;55(21):3065-3068. doi: 10.1039/c8cc10074h.

Authors

Mengyi Xiong¹, Qiming Rong, Gezhi Kong, Chan Yang, Yan Zhao, Feng-Li Qu, Xiao-Bing Zhang, Weihong Tan

Affiliation

¹ Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. xbzhang@hnu.edu.cn.

PMID: 30785144
DOI: 10.1039/c8cc10074h

Abstract

Precision diagnosis and effective treatment are the cores of early cancer therapy. Here, for the first time, we report a hybridization chain reaction-based nanoprobe for selective and sensitive cancer cell recognition and amplified photodynamic therapy.

MeSH terms

Adsorption
Cell Survival / drug effects
Chlorophyllides
DNA / administration & dosage
DNA / chemistry
DNA / pharmacology*
Drug Delivery Systems / methods
Graphite / chemistry
HEK293 Cells
HeLa Cells
Humans
Neoplasms / drug therapy*
Nucleic Acid Hybridization / methods
Photochemotherapy / methods*
Photosensitizing Agents / administration & dosage
Photosensitizing Agents / chemistry
Photosensitizing Agents / pharmacology*
Porphyrins / administration & dosage
Porphyrins / chemistry
Porphyrins / pharmacology*

Substances

Chlorophyllides
Photosensitizing Agents
Porphyrins
graphene oxide
phytochlorin
Graphite
DNA