Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development

Leukemia. 2019 Jun;33(6):1535-1539. doi: 10.1038/s41375-019-0377-0. Epub 2019 Jan 23.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cell Proliferation
  • Cell Self Renewal*
  • Leukemia, Experimental / etiology*
  • Leukemia, Experimental / pathology
  • Mice
  • Mice, Knockout
  • Neoplastic Stem Cells / metabolism
  • Neoplastic Stem Cells / pathology*
  • Tandem Repeat Sequences
  • Tumor Suppressor Protein p53 / physiology*
  • fms-Like Tyrosine Kinase 3 / physiology*

Substances

  • Trp53 protein, mouse
  • Tumor Suppressor Protein p53
  • Flt3 protein, mouse
  • fms-Like Tyrosine Kinase 3