Gaining Weight: Insulin-Eating Islet Macrophages

Olga Spadaro; Vishwa Deep Dixit

doi:10.1016/j.immuni.2018.12.026

Gaining Weight: Insulin-Eating Islet Macrophages

Immunity. 2019 Jan 15;50(1):13-15. doi: 10.1016/j.immuni.2018.12.026.

Authors

Olga Spadaro¹, Vishwa Deep Dixit²

Affiliations

¹ Department of Comparative Medicine and Yale Center for Research on Aging, New Haven, CT 06520, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.
² Department of Comparative Medicine and Yale Center for Research on Aging, New Haven, CT 06520, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address: vishwa.dixit@yale.edu.

PMID: 30650372
DOI: 10.1016/j.immuni.2018.12.026

Abstract

The role of the immune system in homeostasis of pancreatic β cells in type 2 diabetes mellitus is poorly characterized. In a recent issue of Cell Metabolism, Ying et al. (2018) report that two subpopulations of macrophages expand during obesity to impair β cell function.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Cell Proliferation
Diabetes Mellitus, Type 2*
Humans
Inflammation
Insulin
Islets of Langerhans*
Macrophages
Obesity

Substances

Insulin

Grants and funding

P01 AG051459/AG/NIA NIH HHS/United States