Hijacking EMT: Better Fat Than Dead

Stefan Hinz; Mark A LaBarge

doi:10.1016/j.ccell.2018.12.007

Hijacking EMT: Better Fat Than Dead

Cancer Cell. 2019 Jan 14;35(1):1-2. doi: 10.1016/j.ccell.2018.12.007.

Authors

Stefan Hinz¹, Mark A LaBarge²

Affiliations

¹ Department of Population Sciences, Beckman Research Institute at City of Hope, Duarte, CA 91010, USA.
² Department of Population Sciences, Beckman Research Institute at City of Hope, Duarte, CA 91010, USA. Electronic address: mlabarge@coh.org.

PMID: 30645968
DOI: 10.1016/j.ccell.2018.12.007

Abstract

Potential for cancers to form metastases requires cell dissemination utilizing epithelial-to-mesenchymal transition (EMT) program. In this issue of Cancer Cell, Ishay-Ronen et al. show that plasticity intrinsic to the EMT program can be exploited to divert cancer cells into becoming post-mitotic adipocytes, thus preventing formation of metastases.

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MeSH terms

Adipocytes
Breast Neoplasms*
Epithelial-Mesenchymal Transition
Humans
Neoplastic Stem Cells