A Self-Assembled ATP Probe for Melanoma Cell Imaging

Chemistry. 2019 Mar 7;25(14):3501-3504. doi: 10.1002/chem.201806182. Epub 2019 Feb 4.

Abstract

In this investigation, a new terpyridine metal complex was developed as a probe for selective detection of ATP and imaging of melanoma cells. The probe takes advantage of the ability of the metal complex to be transformed to its imaging competent turn-on state through assembly with ATP.

Keywords: ATP; melanoma; optical imaging; supramolecular chemistry; theranostics.

MeSH terms

  • Adenosine Triphosphate / analysis*
  • Cell Line, Tumor
  • Coordination Complexes / chemistry*
  • Fluorescent Dyes / chemistry*
  • Humans
  • Melanoma / diagnostic imaging*
  • Models, Molecular
  • Optical Imaging / methods
  • Pyridines / chemistry*

Substances

  • Coordination Complexes
  • Fluorescent Dyes
  • Pyridines
  • Adenosine Triphosphate