Measuring Treatment Response in Pharmacological and Lifestyle Interventions Using Electroencephalography in ADHD: A Review

Clin EEG Neurosci. 2019 Jul;50(4):256-266. doi: 10.1177/1550059418817966. Epub 2019 Jan 9.

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, and/or impulsivity with associations to short- and long-term aversive life events. The exact etiology of the disorder is still unknown. ADHD is heterogeneous in symptomology and a single consistent, reliable biomarker has not been found. Quantitative electroencephalography (EEG) has been proposed as a potential way to differentiate those with ADHD from typically developing controls; however, the data on the diagnostic utility of this approach have been variable. Quantitative EEG has been employed in prognostic ways to assess differences in baseline spectral power profiles and pharmacological and nonpharmacological treatment effects on electrocortical activity within the ADHD population. The aim of this review is to summarize the literature investigating the degree of normalization of resting-state EEG profiles in individuals with ADHD through various interventions, including stimulant and nonstimulant medication, exercise, and diet.

Keywords: ADHD; EEG; biomarker; diet; electroencephalography; exercise; pharmacological treatment.

Publication types

  • Review

MeSH terms

  • Attention Deficit Disorder with Hyperactivity / diagnostic imaging*
  • Attention Deficit Disorder with Hyperactivity / physiopathology*
  • Attention Deficit Disorder with Hyperactivity / therapy*
  • Biomarkers
  • Brain / diagnostic imaging*
  • Brain / physiopathology
  • Central Nervous System Stimulants / therapeutic use
  • Electroencephalography*
  • Exercise Therapy
  • Humans
  • Life Style
  • Risk Reduction Behavior*
  • Treatment Outcome

Substances

  • Biomarkers
  • Central Nervous System Stimulants