Dynamic split G-quadruplex programmed reversible nanodevice

Chem Commun (Camb). 2019 Jan 2;55(3):389-392. doi: 10.1039/c8cc08744j.

Abstract

We propose a dynamic nanodevice based on a split G-quadruplex (G4). By splitting it apart, we can successfully decouple the G-tetrad formation from external stimuli, greatly expanding the stimulus for G4 based devices. Taking advantage of the rigid force from a DNA duplex, the nanodevice can be switched reversibly through the conformational transformation.

MeSH terms

  • DNA / chemistry*
  • G-Quadruplexes*
  • MicroRNAs / analysis*
  • Nanotechnology*

Substances

  • MicroRNAs
  • DNA