Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction

Gut. 2020 Jan;69(1):191-193. doi: 10.1136/gutjnl-2018-317726. Epub 2018 Dec 5.

Joeri Tulkens^{1

2}, Glenn Vergauwen^{1

2

3}, Jan Van Deun^{1

2}, Edward Geeurickx^{1

2}, Bert Dhondt^{1

2

4}, Lien Lippens^{1

2

5}, Marie-Angélique De Scheerder⁶, Ilkka Miinalainen⁷, Pekka Rappu⁸, Bruno G De Geest^{2

9}, Katrien Vandecasteele^{2

10}, Debby Laukens^{11

12}, Linos Vandekerckhove⁶, Hannelore Denys^{2

5}, Jo Vandesompele^{2

13}, Olivier De Wever^{1

2}, An Hendrix^{1

2}

¹ Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University, Ghent, Belgium.
² Cancer Research Institute Ghent, Ghent University, Ghent, Belgium.
³ Department of Gynaecology, Ghent University Hospital, Ghent, Belgium.
⁴ Department of Urology, Ghent University Hospital, Ghent, Belgium.
⁵ Department of Medical Oncology, Ghent University Hospital, Ghent, Belgium.
⁶ Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium.
⁷ Biocenter Oulu, University of Oulu, Oulu, Finland.
⁸ Department of Biochemistry, University of Turku, Turku, Finland.
⁹ Department of Pharmaceutics, Ghent University, Ghent, Belgium.
¹⁰ Department of Radiation Oncology and Experimental Cancer Research, Ghent University, Ghent, Belgium.
¹¹ Department of Gastroenterology, Ghent University, Ghent, Belgium.
¹² Ghent Gut Inflammation Group, Ghent University, Ghent, Belgium.
¹³ Center for Medical Genetics, Ghent University, Ghent, Belgium.

No abstract available

Keywords: HIV/AIDS; IBD; cancer; endotoxin; intestinal barrier function.

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