T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development

Haematologica. 2019 May;104(5):e204-e207. doi: 10.3324/haematol.2018.198424. Epub 2018 Dec 4.
No abstract available

Publication types

  • Letter

MeSH terms

  • Cadherins / genetics
  • Cadherins / metabolism*
  • Gene Expression Regulation, Leukemic*
  • Humans
  • Mutation*
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / metabolism
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology*
  • Protein Isoforms
  • Receptor, Notch1 / genetics*
  • T-Lymphocytes / metabolism
  • T-Lymphocytes / pathology*
  • Tumor Cells, Cultured

Substances

  • Cadherins
  • FAT1 protein, human
  • NOTCH1 protein, human
  • Protein Isoforms
  • Receptor, Notch1