Cerebrospinal fluid interleukin (IL)-10 and IL-10:IL-6 ratio as biomarkers for small B-cell lymphoproliferations with leptomeningeal dissemination

Myrto Costopoulos; Rathana Kim; Sylvain Choquet; Karim Maloum; Caroline Houillier; Caroline Algrin; Catherine Settegrana; Juliette Villemonteix; Martine Brissard; Claire Quiney; Sophie Bernard; Frederic Davi; Catherine Thieblemont; Khe Hoang-Xuan; Veronique Leblond; Helene Merle-Beral; Magali Le Garff-Tavernier

doi:10.1053/j.seminhematol.2017.06.005

Cerebrospinal fluid interleukin (IL)-10 and IL-10:IL-6 ratio as biomarkers for small B-cell lymphoproliferations with leptomeningeal dissemination

Semin Hematol. 2018 Oct;55(4):179-181. doi: 10.1053/j.seminhematol.2017.06.005. Epub 2017 Jul 6.

Authors

Myrto Costopoulos¹, Rathana Kim², Sylvain Choquet³, Karim Maloum², Caroline Houillier⁴, Caroline Algrin³, Catherine Settegrana², Juliette Villemonteix², Martine Brissard², Claire Quiney², Sophie Bernard⁵, Frederic Davi⁶, Catherine Thieblemont⁵, Khe Hoang-Xuan⁷, Veronique Leblond⁸, Helene Merle-Beral⁶, Magali Le Garff-Tavernier⁹

Affiliations

¹ Department of Biological Hematology, Pitie-Salpetriere Hospital, Paris, France; Sorbonne Universités, UPMC, Paris, France; Centre de Recherche des Cordeliers, Cell Death and Drug Resistance in Lymphoproliferative Disorders, Paris, France. Electronic address: myrto.costopoulos@aphp.fr.
² Department of Biological Hematology, Pitie-Salpetriere Hospital, Paris, France.
³ Department of Clinical Hematology, Pitie-Salpetriere Hospital, Paris, France.
⁴ Department of Neuro-Oncology, Pitie-Salpetriere Hospital, Paris, France.
⁵ APHP, Saint-Louis Hospital, Hemato-oncology Department and Paris Cité Sorbonne Diderot 7 University, Paris, France.
⁶ Department of Biological Hematology, Pitie-Salpetriere Hospital, Paris, France; Sorbonne Universités, UPMC, Paris, France; Centre de Recherche des Cordeliers, Cell Death and Drug Resistance in Lymphoproliferative Disorders, Paris, France.
⁷ Sorbonne Universités, UPMC, Paris, France; Department of Neuro-Oncology, Pitie-Salpetriere Hospital, Paris, France.
⁸ Sorbonne Universités, UPMC, Paris, France; Department of Clinical Hematology, Pitie-Salpetriere Hospital, Paris, France.
⁹ Department of Biological Hematology, Pitie-Salpetriere Hospital, Paris, France; Centre de Recherche des Cordeliers, Cell Death and Drug Resistance in Lymphoproliferative Disorders, Paris, France.

PMID: 30502843
DOI: 10.1053/j.seminhematol.2017.06.005

Abstract

We here report for the first time that low levels of interleukin (IL)-10 do not exclude lymphomatous meningitis (LM) in B-cell lymphoproliferative disorders (CLPD). Unexpectedly, IL-10 levels and IL-10:IL-6 ratio in CLPD differed from the levels observed in diffuse large B-cell lymphoma (DLBCL). We report the usefulness of adding the IL-10:IL-6 ratio in order to potentially reveal more aggressive lymphomas: either a transformation or an association with another "hidden" lymphoma such as primary CNS lymphoma (PCNSL).

Publication types

Multicenter Study

MeSH terms

Aged
Aged, 80 and over
Biomarkers / cerebrospinal fluid*
Central Nervous System Neoplasms / diagnosis*
Central Nervous System Neoplasms / pathology
Female
Humans
Interleukin-10 / metabolism*
Interleukin-6 / metabolism*
Male
Middle Aged

Substances

Biomarkers
Interleukin-6
Interleukin-10