Ortho-Biologics for Osteoarthritis

Kyla Huebner; Rachel M Frank; Alan Getgood

doi:10.1016/j.csm.2018.09.002

Ortho-Biologics for Osteoarthritis

Clin Sports Med. 2019 Jan;38(1):123-141. doi: 10.1016/j.csm.2018.09.002.

Authors

Kyla Huebner¹, Rachel M Frank², Alan Getgood³

Affiliations

¹ Division of Orthopaedic Surgery, Western University, Fowler Kennedy Sports Medicine Clinic, 3M Centre, 1151 Richmond Street, London, Ontario N6A 3K7, Canada.
² University of Colorado, Boulder, CO, USA.
³ Division of Orthopaedic Surgery, Western University, Fowler Kennedy Sports Medicine Clinic, 3M Centre, 1151 Richmond Street, London, Ontario N6A 3K7, Canada. Electronic address: agetgoo@uwo.ca.

PMID: 30466718
DOI: 10.1016/j.csm.2018.09.002

Abstract

Osteoarthritis (OA) is a debilitation condition that affects millions of North Americans. Aside from weight loss, activity modification, and joint replacement, little else has been effective in delaying the progression of OA or treating the symptoms of OA. Ortho-biologics have become a popular treatment option in a variety of musculoskeletal conditions, including OA. In this article, the authors explore the use of 4 key ortho-biologics in the treatment of OA, all of which have shown promising results in the literature, despite the lack of large randomized controlled trials.

Keywords: Autologous conditioned serum; Bone marrow; Osteoarthritis; PRP; Stem cell.

Publication types

Review

MeSH terms

Adipose Tissue / cytology
Animals
Biological Products / therapeutic use*
Bone Marrow
Humans
Hyaluronic Acid
Osteoarthritis / therapy*
Platelet-Rich Plasma
Serum
Stem Cell Transplantation

Substances

Biological Products
Hyaluronic Acid