Report of Resistant Varicella Zoster Infection Treated With Donor Lymphocyte Infusion in a Pediatric Oncology Patient

Pediatr Infect Dis J. 2019 May;38(5):513-515. doi: 10.1097/INF.0000000000002252.

Abstract

We report an 8-year-old boy with disseminated, life-threatening, drug treatment-resistant varicella zoster infection occurring during standard treatment for neuroblastoma in whom viral clearance and cure was effected by donor Lymphocyte infusion from his HLA (Human leukocyte antigen)-identical twin sibling.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Drug Resistance, Viral*
  • Herpes Zoster / therapy*
  • Herpes Zoster / virology
  • Herpesvirus 3, Human / drug effects
  • Herpesvirus 3, Human / isolation & purification
  • Humans
  • Immunotherapy, Adoptive / methods*
  • Lymphocytes / immunology*
  • Male
  • Neuroblastoma / complications*
  • Neuroblastoma / therapy
  • Treatment Outcome