[Experimental Enterobacter cloacae endocarditis treated with gentamicin. Predictive value of the in vitro bactericidal rate]

G Potel; J Caillon; D Bugnon; P Lecomte; H B Drugeon; D Baron

[Experimental Enterobacter cloacae endocarditis treated with gentamicin. Predictive value of the in vitro bactericidal rate]

Pathol Biol (Paris). 1988 May;36(5):536-9.

[Article in French]

Authors

G Potel¹, J Caillon, D Bugnon, P Lecomte, H B Drugeon, D Baron

Affiliation

¹ Laboratoire d'Antibiologie, Faculté de Médecine, 1, Nantes.

PMID: 3043353

Abstract

The predictive value of in vitro time-kill curve was tested on an Enterobacter cloacae endocarditis experimental model. The antibiotic studied was gentamicin. Despite a similar MIC, 2 Enterobacter cloacae strains exhibited very different time-kill curves in vitro. This difference was found being predictive of efficacy on the in vivo model, 24 hours after a single injection of gentamicin.

Publication types

Comparative Study
English Abstract

MeSH terms

Animals
Endocarditis, Bacterial / drug therapy*
Enterobacter / drug effects*
Enterobacteriaceae / drug effects*
Enterobacteriaceae Infections / drug therapy*
Female
Gentamicins / pharmacology
Gentamicins / therapeutic use*
Microbial Sensitivity Tests
Rabbits

Substances

Gentamicins