STRring up Cancer with lncRNA

Jodi Bubenik; Maurice S Swanson

doi:10.1016/j.molcel.2018.10.026

STRring up Cancer with lncRNA

Mol Cell. 2018 Nov 1;72(3):399-401. doi: 10.1016/j.molcel.2018.10.026.

Authors

Jodi Bubenik¹, Maurice S Swanson²

Affiliations

¹ Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida College of Medicine, Gainesville, FL 32610, USA.
² Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida College of Medicine, Gainesville, FL 32610, USA. Electronic address: mswanson@ufl.edu.

PMID: 30388407
DOI: 10.1016/j.molcel.2018.10.026

Abstract

In this issue of Molecular Cell, Yap et al. (2018) identify a novel lncRNA (PNCTR) that contains short tandem repeats that trap the RNA splicing factor PTBP1 in the perinucleolar compartment and link this sequestration activity to cancer cell development.

Publication types

Comment

MeSH terms

Alternative Splicing*
Cell Survival
Microsatellite Repeats
Polypyrimidine Tract-Binding Protein / genetics
RNA, Long Noncoding*

Substances

RNA, Long Noncoding
Polypyrimidine Tract-Binding Protein

Grants and funding

U54 NS048843/NS/NINDS NIH HHS/United States