Circular RNAs in Cardiovascular Diseases

Lijun Wang; Xiangmin Meng; Guoping Li; Qiulian Zhou; Junjie Xiao

doi:10.1007/978-981-13-1426-1_15

Circular RNAs in Cardiovascular Diseases

Adv Exp Med Biol. 2018:1087:191-204. doi: 10.1007/978-981-13-1426-1_15.

Authors

Lijun Wang^{1

2}, Xiangmin Meng^{1

2}, Guoping Li³, Qiulian Zhou^{1

2

4}, Junjie Xiao⁵

Affiliations

¹ Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, China.
² Shanghai Key Laboratory of Bio-Energy Crops, School of Life Sciences, Shanghai University, Shanghai, China.
³ Cardiovascular Division of the Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
⁴ Shanghai Applied Radiation Institute, School of Environmental and Chemical Engineering, Shanghai University, Shanghai, China.
⁵ School of Life Science, Institute of Cardiovascular Sciences, Shanghai University, Shanghai, China. junjiexiao@shu.edu.cn.

PMID: 30259367
DOI: 10.1007/978-981-13-1426-1_15

Abstract

Circular RNAs (circRNAs), a group of circular RNA molecules with a 3',5'-phosphodiester bond at the junction site, are generated by back-splicing of precursor mRNAs. Most of the circular RNAs originate from the exon region of the encoded protein, and some are derived from intron regions, antisense transcripts, or long noncoding RNAs. Circular RNAs are abundantly in eukaryotic transcriptome and participate in various biological processes. It is closely associated with various diseases such as tumors, diabetes, nervous system diseases, and cardiovascular diseases. In cardiovascular system, numerous circRNAs have been identified and involved in important processes of cardiovascular development and diseases. Here we will review the latest research progress of circular RNA in cardiovascular diseases. Also, we will outline the specific examples of circRNAs involved in cardiovascular system regulatory effects, including act as miRNA sponges, interaction with RNA-binding proteins, regulated by RNA-binding proteins and serve as biomarkers. In addition, potential mechanisms underlying the regulatory role of circRNAs in cardiovascular diseases will be discussed.

Keywords: Cardiovascular diseases; Circular RNA; RNA-binding protein; microRNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alternative Splicing
Animals
Body Fluids / chemistry
Cardiovascular Diseases / diagnosis
Cardiovascular Diseases / genetics*
Forecasting
Gene Expression Regulation / genetics
Humans
MicroRNAs / metabolism
Nucleic Acid Conformation
RNA / analysis
RNA / genetics*
RNA / metabolism
RNA, Circular
RNA, Long Noncoding / analysis
RNA, Long Noncoding / genetics
RNA, Long Noncoding / metabolism
RNA-Binding Proteins / metabolism

Substances

MicroRNAs
RNA, Circular
RNA, Long Noncoding
RNA-Binding Proteins
RNA