Cisd2 haploinsufficiency: A driving force for hepatocellular carcinoma

Zhao-Qing Shen; Yi-Long Huang; Ting-Fen Tsai

doi:10.1080/23723556.2018.1441627

Cisd2 haploinsufficiency: A driving force for hepatocellular carcinoma

Mol Cell Oncol. 2018 Mar 13;5(3):e1441627. doi: 10.1080/23723556.2018.1441627. eCollection 2018.

Authors

Zhao-Qing Shen¹, Yi-Long Huang¹, Ting-Fen Tsai^{1

2

3

4}

Affiliations

¹ Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan.
² Aging and Health Research Center, National Yang-Ming University, Taipei, Taiwan.
³ Genome Research Center, National Yang-Ming University, Taipei, Taiwan.
⁴ Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan.

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is the major risk factor leading to hepatocellular carcinoma (HCC). Cisd2 haploinsufficiency in mice causes NAFLD by disrupting Ca²⁺ homeostasis, indicating that CISD2 is a molecular target for the treatment of NAFLD and the prevention of HCC.

Keywords: CISD2; ER stress; Serca2b; calcium homeostasis; haploinsufficiency; hepatocellular carcinoma; nonalcoholic fatty liver disease; tumor suppressor gene.

Grants and funding

This work was supported by the Ministry of Science and Technology, NSC99-2628-B-010-001-MY3; Ministry of Science and Technology, MOST 104-3011-B-010-001; Ministry of Science and Technology, MOST 103-2633-B-400-002.