CircRNA microarray profiling identifies a novel circulating biomarker for detection of gastric cancer

Mol Cancer. 2018 Sep 20;17(1):137. doi: 10.1186/s12943-018-0888-8.

Abstract

CircRNA expression profiles for gastric cancer (GC) were screened using plasma samples from 10 GC patients with different TNM stages and 5 healthy individuals as controls. Results showed lower expression of circ-KIAA1244 in GC tissues, plasmas, and cells compare to normal controls. Further clinical data analysis demonstrated that a decreased expression of circ-KIAA1244 in plasmas was negatively correlated with TNM stage and lymphatic metastasis, and a shorter overall survival time of GC patients. Moreover, we found that circ-KIAA1244 could be detected in GC plasma exosomes and showed no obvious significance compared to the expression level in the corresponding plasmas. This study revealed a GC-tissues-derived circ-KIAA1244 could serve a novel circulating biomarker for detection of GC.

Keywords: Biomarker; Exosomes; Microarray; Plasma; circRNAs.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor*
  • Case-Control Studies
  • Cell-Free Nucleic Acids*
  • Computational Biology / methods
  • Female
  • Gene Expression Profiling / methods
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Neoplasm Staging
  • Prognosis
  • RNA / genetics*
  • RNA, Circular
  • RNA, Untranslated / genetics*
  • Stomach Neoplasms / blood
  • Stomach Neoplasms / diagnosis*
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / mortality

Substances

  • Biomarkers, Tumor
  • Cell-Free Nucleic Acids
  • RNA, Circular
  • RNA, Untranslated
  • RNA