Abstract
Despite substantial recent advances, bona fide regeneration of the damaged human heart is still an unmet ambition. By extracting our current knowledge from developmental biology, animal models of heart regeneration, and clinical observations, we propose five hallmarks of cardiac regeneration and suggest a holistic approach to reconstituting human heart function.
Publication types
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Introductory Journal Article
MeSH terms
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Animals
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Fibrosis
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Heart Diseases / immunology
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Heart Diseases / pathology
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Heart Diseases / physiopathology
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Heart Diseases / therapy*
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Humans
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Muscle Development*
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Myocardium* / immunology
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Myocardium* / metabolism
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Myocardium* / pathology
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Neovascularization, Physiologic*
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Recovery of Function
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Regenerative Medicine / methods*
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Treatment Outcome
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Ventricular Remodeling*