Association of body mass index with mortality in cardiovascular disease: New insights into the obesity paradox from multiple perspectives

Trends Cardiovasc Med. 2019 May;29(4):220-225. doi: 10.1016/j.tcm.2018.08.006. Epub 2018 Aug 22.

Abstract

Over the past 4 decades, prevalence of obesity has increased rapidly at both the national and global level and presents a major public health challenge. Obesity is associated with increased risk of morbidity from cardiovascular diseases. Data suggesting that the presence of obesity may be protective in individuals with clinically manifest cardiovascular disease have led to discussion of an "obesity paradox", stirring controversy and leading to unclear messaging regarding the true health risks of excess weight. This review explores the relationship between obesity and fatal and non-fatal outcomes in patients with prevalent cardiovascular disease and offers novel insights into the obesity paradox.

Keywords: BMI; Cardiovascular disease; Mortality.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adiposity
  • Body Mass Index*
  • Cardiovascular Diseases / diagnosis
  • Cardiovascular Diseases / mortality*
  • Cardiovascular Diseases / physiopathology
  • Cause of Death
  • Humans
  • Obesity / diagnosis
  • Obesity / mortality*
  • Obesity / physiopathology
  • Prevalence
  • Prognosis
  • Risk Assessment
  • Risk Factors