Abstract
The mcr-1 gene encodes a phosphoethanolamine transferase that confers resistance to colistin by transferring phosphoethanolamine to lipid A. A 33-kb IncX4 plasmid harboring mcr-1 was detected in a Klebsiella pneumoniae isolate and two Escherichia coli isolates, and a 66-kb IncI2 plasmid was detected in three E. coli isolates in hospitals in Okinawa, Japan.
Keywords:
Colistin resistance; IncX4 plasmid harboring mcr-1; MCR-1 producing Klebsiella pneumoniae.
Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Colistin / pharmacology
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Drug Resistance, Bacterial
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Escherichia coli / enzymology
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Escherichia coli / genetics
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Escherichia coli / isolation & purification
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Escherichia coli Proteins / genetics
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Escherichia coli Proteins / metabolism
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Humans
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Japan
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Klebsiella Infections / microbiology
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Klebsiella pneumoniae / drug effects
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Klebsiella pneumoniae / enzymology
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Klebsiella pneumoniae / genetics
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Klebsiella pneumoniae / isolation & purification*
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Methyltransferases / genetics
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Methyltransferases / metabolism*
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Plasmids / genetics*
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Plasmids / metabolism
Substances
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Anti-Bacterial Agents
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Escherichia coli Proteins
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MCR-1 protein, E coli
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Methyltransferases
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phosphoethanolamine methyltransferase
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Colistin