Multiple Placental Infarcts in a Pregnant Woman with Essential Thrombocythemia

Intern Med. 2018 Dec 15;57(24):3647-3650. doi: 10.2169/internalmedicine.1311-18. Epub 2018 Aug 10.

Abstract

Myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia (ET), and primary myelofibrosis, mainly occur in older patients, but have also been reported in younger patients. A "second peak" occurs in female patients in their thirties, particularly in ET; thus, the management of pregnancy is often discussed. We herein present the case of a 33-year-old woman with a high platelet count and multiple placental infarcts during delivery who was subsequently diagnosed with ET. Although there are no worldwide guidelines for the management of MPNs in pregnancy, the risk of thrombosis is markedly increased in these patients, and antithrombotic therapy should be considered.

Keywords: aspirin; essential thrombocythemia; low-molecular-weight heparin; myeloproliferative neoplasms; placental infarcts; pregnancy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Fibrinolytic Agents / therapeutic use
  • Humans
  • Infarction / complications
  • Infarction / diagnosis*
  • Placenta / blood supply*
  • Platelet Count
  • Pregnancy
  • Pregnancy Complications, Hematologic / diagnosis*
  • Risk Factors
  • Thrombocythemia, Essential / complications
  • Thrombocythemia, Essential / diagnosis*
  • Thrombosis / etiology
  • Thrombosis / prevention & control

Substances

  • Fibrinolytic Agents