Distinguishing Zika and Dengue Viruses through Simple Clinical Assessment, Singapore

Emerg Infect Dis. 2018 Aug;24(8):1565-1568. doi: 10.3201/eid2408.171883.

Abstract

Dengue virus and Zika virus coexist in tropical regions in Asia where healthcare resources are limited; differentiating the 2 viruses is challenging. We showed in a case-control discovery cohort, and replicated in a validation cohort, that the diagnostic indices of conjunctivitis, platelet count, and monocyte count reliably distinguished between these viruses.

Keywords: Singapore; Southeast Asia; Zika virus; conjunctivitis; dengue virus; platelets; viruses; zoonoses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aedes / virology
  • Aged
  • Animals
  • Case-Control Studies
  • Cohort Studies
  • Conjunctivitis, Viral / diagnosis
  • Conjunctivitis, Viral / physiopathology
  • Conjunctivitis, Viral / virology
  • Dengue / diagnosis*
  • Dengue / physiopathology
  • Dengue / transmission
  • Dengue / virology
  • Dengue Virus
  • Diagnosis, Differential
  • Female
  • Fever / diagnosis
  • Fever / physiopathology
  • Fever / virology
  • Humans
  • Leukocyte Count
  • Male
  • Middle Aged
  • Mosquito Vectors / virology
  • Myalgia / diagnosis
  • Myalgia / physiopathology
  • Myalgia / virology
  • Platelet Count
  • ROC Curve
  • Singapore
  • Zika Virus
  • Zika Virus Infection / diagnosis*
  • Zika Virus Infection / physiopathology
  • Zika Virus Infection / transmission
  • Zika Virus Infection / virology