Microdeletion of 7p12.1p13, including IKZF1, causes intellectual impairment, overgrowth, and susceptibility to leukaemia

Br J Haematol. 2019 Apr;185(2):354-357. doi: 10.1111/bjh.15494. Epub 2018 Jul 13.

Tekla Järviaho^{1

2

3}, Vasilios Zachariadis^{4

5}, Bianca Tesi^{5

6}, Samuel Chiang⁷, Yenan T Bryceson^{7

8}, Merja Möttönen^{1

9}, Riitta Niinimäki^{1

9}, Benedicte Bang⁴, Elisa Rahikkala^{1

2

10}, Fulya Taylan⁴, Johanna Uusimaa^{1

2

3

9}, Arja Harila-Saari¹¹, Ann Nordgren^{4

5}

¹ PEDEGO Research Unit, University of Oulu, Oulu, Finland.
² Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland.
³ Biocenter Oulu, University of Oulu, Oulu, Finland.
⁴ Department of Molecular Medicine and Surgery, Center of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
⁵ Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
⁶ Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.
⁷ Center for Hematology and Regenerative Medicine (HERM), Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
⁸ Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
⁹ Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland.
¹⁰ Department of Clinical Genetics, Oulu University Hospital, Oulu, Finland.
¹¹ Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

No abstract available

Keywords: IKAROS; acute lymphoblastic leukaemia; cancer genetics; childhood leukaemia; genetic disorders.

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