Development of a TaqMan probe-based quantitative reverse transcription PCR assay for detection of Getah virus RNA

Arch Virol. 2018 Oct;163(10):2877-2881. doi: 10.1007/s00705-018-3927-2. Epub 2018 Jul 9.

Abstract

Getah virus (GETV), a mosquito-borne virus that mainly infects horses and pigs, has emerged and spread in China. We developed a highly specific and reproducible TaqMan probe-based quantitative reverse transcription PCR (RT-qPCR) assay targeting the non-structural protein 1 of GETV, whose detection limit is 25.5 copies/µL, which is 100-fold higher than that of conventional RT-PCR. RT-qPCR was used to detect GETV RNA in mosquito and animal clinical samples, showing that the accuracy of RT-qPCR was higher than that of conventional RT-PCR. The newly developed RT-qPCR assay may be a useful alternative tool for rapid, simple and specific diagnosis of GETV infection.

MeSH terms

  • Alphavirus / genetics*
  • Alphavirus / isolation & purification
  • Animals
  • Base Sequence
  • China
  • Culex / virology*
  • DNA Probes / genetics*
  • Horses
  • RNA, Viral / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction / methods*
  • Sus scrofa
  • Viral Nonstructural Proteins / genetics*

Substances

  • DNA Probes
  • RNA, Viral
  • Viral Nonstructural Proteins