MitoCPR: Meticulous Monitoring of Mitochondrial Proteostasis

Radha Desai; Michelangelo Campanella

doi:10.1016/j.molcel.2018.06.027

MitoCPR: Meticulous Monitoring of Mitochondrial Proteostasis

Mol Cell. 2018 Jul 5;71(1):8-9. doi: 10.1016/j.molcel.2018.06.027.

Authors

Radha Desai¹, Michelangelo Campanella²

Affiliations

¹ Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, NW1 0TU London, UK.
² Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, NW1 0TU London, UK; Consortium for Mitochondrial Research (CfMR), University College London, Gower Street, WC1E 6BT London, UK. Electronic address: mcampanella@rvc.ac.uk.

PMID: 29979970
DOI: 10.1016/j.molcel.2018.06.027

Abstract

Mitochondrial protein import stress compromises functioning of the organelles, due to inadequate supply of inner mitochondrial proteins. Weidberg and Amon (2018) describe a new monitoring pathway in budding yeast, which restores mitochondrial function following the clearing of accumulated unfolded pre-transported mitochondrial proteins, by devising a molecular strategy of overexpressing bi-partite-containing mitochondrial proteins.

Publication types

Comment

MeSH terms

Mitochondria*
Mitochondrial Proteins
Protein Transport
Proteostasis*

Substances

Mitochondrial Proteins