Abstract
New promising treatment options for chronic inflammatory bowel diseases, confirm the expanded pathophysiological understanding in terms of the interactions of the gastrointestinal microbiome with the adaptive and innate immune response and barrier protection. Therefore, these interrelations are focus of research and therapeutic strategies. The following review will give insights into the pathomechanisms, current treatment options and future developments.
© Georg Thieme Verlag KG Stuttgart · New York.
MeSH terms
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Anti-Bacterial Agents / therapeutic use
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Antibodies, Monoclonal / adverse effects
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Antibodies, Monoclonal / therapeutic use
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Antibodies, Monoclonal, Humanized / adverse effects
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Antibodies, Monoclonal, Humanized / therapeutic use
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Clinical Trials as Topic
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Colitis, Ulcerative / immunology
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Colitis, Ulcerative / therapy*
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Crohn Disease / immunology
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Crohn Disease / therapy*
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Defensins / adverse effects
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Defensins / therapeutic use
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Fecal Microbiota Transplantation
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Humans
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Immunosuppressive Agents / adverse effects
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Immunosuppressive Agents / therapeutic use
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Integrins / antagonists & inhibitors
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Lecithins / therapeutic use
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Probiotics / adverse effects
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Probiotics / therapeutic use
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Ustekinumab / therapeutic use
Substances
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Anti-Bacterial Agents
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Defensins
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Immunosuppressive Agents
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Integrins
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Lecithins
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integrin alpha4beta7
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vedolizumab
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Ustekinumab