Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates

Dawn M Dudley; Koen K Van Rompay; Lark L Coffey; Amir Ardeshir; Rebekah I Keesler; Eliza Bliss-Moreau; Peta L Grigsby; Rosemary J Steinbach; Alec J Hirsch; Rhonda P MacAllister; Heidi L Pecoraro; Lois M Colgin; Travis Hodge; Daniel N Streblow; Suzette Tardif; Jean L Patterson; Manasi Tamhankar; Maxim Seferovic; Kjersti M Aagaard; Claudia Sánchez-San Martín; Charles Y Chiu; Antonito T Panganiban; Ronald S Veazey; Xiaolei Wang; Nicholas J Maness; Margaret H Gilbert; Rudolf P Bohm; Kristina M Adams Waldorf; Michael Gale Jr; Lakshmi Rajagopal; Charlotte E Hotchkiss; Emma L Mohr; Saverio V Capuano 3rd; Heather A Simmons; Andres Mejia; Thomas C Friedrich; Thaddeus G Golos; David H O'Connor

doi:10.1038/s41591-018-0088-5

Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates

Nat Med. 2018 Aug;24(8):1104-1107. doi: 10.1038/s41591-018-0088-5. Epub 2018 Jul 2.

Authors

Dawn M Dudley¹, Koen K Van Rompay^{2

3}, Lark L Coffey⁴, Amir Ardeshir⁵, Rebekah I Keesler⁵, Eliza Bliss-Moreau⁵, Peta L Grigsby⁶, Rosemary J Steinbach⁶, Alec J Hirsch^{7

8}, Rhonda P MacAllister⁹, Heidi L Pecoraro¹⁰, Lois M Colgin¹⁰, Travis Hodge⁹, Daniel N Streblow^{11

12}, Suzette Tardif¹³, Jean L Patterson¹⁴, Manasi Tamhankar¹⁴, Maxim Seferovic¹⁵, Kjersti M Aagaard^{15

16}, Claudia Sánchez-San Martín¹⁷, Charles Y Chiu^{17

18}, Antonito T Panganiban^{19

20}, Ronald S Veazey²¹, Xiaolei Wang²¹, Nicholas J Maness²², Margaret H Gilbert²³, Rudolf P Bohm²³, Kristina M Adams Waldorf²⁴, Michael Gale Jr^{25

26}, Lakshmi Rajagopal^{27

28}, Charlotte E Hotchkiss²⁹, Emma L Mohr³⁰, Saverio V Capuano 3rd³¹, Heather A Simmons³¹, Andres Mejia³¹, Thomas C Friedrich^{31

32}, Thaddeus G Golos^{31

33}, David H O'Connor^{34

35}

Affiliations

¹ Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA.
² California National Primate Research Center, University of California-Davis, Davis, CA, USA. kkvanrompay@ucdavis.edu.
³ Department of Pathology, Microbiology, and Immunology, University of California-Davis, Davis, CA, USA. kkvanrompay@ucdavis.edu.
⁴ Department of Pathology, Microbiology, and Immunology, University of California-Davis, Davis, CA, USA.
⁵ California National Primate Research Center, University of California-Davis, Davis, CA, USA.
⁶ Department of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Portland, OR, USA.
⁷ Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR, USA.
⁸ Division of Pathobiology and Immunology, Oregon National Primate Research Center, Portland, OR, USA.
⁹ Division of Comparative Medicine, Oregon National Primate Research Center, Portland, OR, USA.
¹⁰ Pathology Services Unit, Division of Comparative Medicine, Oregon National Primate Research Center, Portland, OR, USA.
¹¹ Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR, USA. streblow@ohsu.edu.
¹² Division of Pathobiology and Immunology, Oregon National Primate Research Center, Portland, OR, USA. streblow@ohsu.edu.
¹³ Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX, USA. stardif@txbiomed.org.
¹⁴ Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX, USA.
¹⁵ Departments of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.
¹⁶ Department of Molecular and Human Genetics at Baylor College of Medicine, Houston, TX, USA.
¹⁷ Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
¹⁸ Department of Medicine/Infectious Diseases, University of California, San Francisco, San Francisco, CA, USA.
¹⁹ Division of Microbiology, Tulane National Primate Research Center, New Orleans, LA, USA. apanagani@tulane.edu.
²⁰ Department of Microbiology and Immunology, Tulane University Health Sciences Center, New Orleans, LA, USA. apanagani@tulane.edu.
²¹ Division of Comparative Pathology, Tulane National Primate Research Center, New Orleans, LA, USA.
²² Division of Microbiology, Tulane National Primate Research Center, New Orleans, LA, USA.
²³ Division of Veterinary Medicine, Tulane National Primate Research Center, New Orleans, LA, USA.
²⁴ Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA. adamsk@u.washington.edu.
²⁵ Department of Immunology, University of Washington, Seattle, WA, USA.
²⁶ Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA, USA.
²⁷ Department of Pediatrics, University of Washington, Seattle, WA, USA.
²⁸ Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
²⁹ Washington National Primate Research Center, University of Washington, Seattle, WA, USA.
³⁰ Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
³¹ Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
³² Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
³³ Department of Comparative Biosciences and Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, USA.
³⁴ Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA. dhoconno@wisc.edu.
³⁵ Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA. dhoconno@wisc.edu.

Abstract

Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Abortion, Spontaneous / virology*
Animals
Female
Kaplan-Meier Estimate
Male
Pregnancy
Primates
Stillbirth / veterinary*
Zika Virus / physiology*
Zika Virus Infection / veterinary*

Abstract

Publication types

MeSH terms

Grants and funding